Scaling Aflasafe: From Lab-Based Innovation To Large-Scale Aflatoxin Mitigation Across Africa

Aflatoxin contamination remains a major challenge in sub-Saharan Africa (SSA), threatening food and feed safety, public health, and trade. Farmers, industries, and policymakers need effective, scalable solutions to protect staple crops such as maize, groundnut, and sorghum from aflatoxin.

One of the most promising innovations is biocontrol using native, atoxigenic Aspergillus flavus strains—applied in the field to outcompete toxin-producing fungi. While small-scale trials in Nigeria over 15 years ago demonstrated its potential, scaling up Aflasafe required overcoming significant manufacturing and commercialization barriers.

A recently published article documents how Aflasafe biocontrol products evolved from lab-based research to industrial-scale production, enabling widespread use across SSA. By refining manufacturing processes, developing fit-to-scale production models, and strengthening commercialization strategies, IITA has facilitated the production of thousands of tons of biocontrol products—leading to over a million tons of aflatoxin-safe crops.

Along with partners, the technology has been developed, registered, and transferred to private sector partners in Senegal, Tanzania, and Mozambique, as well as to the public/private sector in Kenya. Product development, testing, registration, and transference are currently at different stages in 23 SSA countries (Fig. 1). Aflasafe technology belongs to the first generation of non-seed technologies of CGIAR to transition successfully from laboratory prototypes to industry applications benefiting farmers and consumers at scale.

This progress underscores the power of effective collaboration among research institutions, private-sector firms, and policymakers. Strengthening public-private partnerships, CGIAR-led research-for-development initiatives, and private-sector investment in manufacturing and distribution (Fig. 2) has been critical to overcoming barriers and accelerating adoption.

The key lesson? Innovation alone is insufficient; scaling solutions like Aflasafe requires developing industrial processes, strategic partnerships, effective commercialization strategies, and sustained investment. As climate change exacerbates aflatoxin risks, urgent action is needed to expand adoption and build resilient food safety systems.